Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often presenting in women of childbearing age. Pregnant women with SLE have a higher risk for complications and outcomes such as preeclampsia, preterm birth, premature rupture of membranes, and pregnancy loss. Additionally, their pregnancy may be complicated by lupus nephritis, a renal and often severe manifestation of lupus flare that presents similarly to preeclampsia.
Dr. Julia Simard and Amadeia Rector will explore the feasibility of disentangling a lupus nephritis flare from preeclampsia. They will go over their recent pilot work, which looks at a series of pregnant patients with SLE diagnosed with preeclampsia that received prenatal care at Lucile Packard Children’s Hospital and were managed for their lupus by Stanford Health Care. Their work aims to characterize the prenatal and postpartum management of a high-risk lupus pregnancy and identify any clinical patterns that may help distinguish preeclampsia from lupus nephritis.