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Clinical Conundrum of Lupus Pregnancy: Can We Distinguish Preeclampsia from Lupus Nephritis Flare?
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often presenting in women of childbearing age. Pregnant women with SLE have a higher risk for complications and outcomes such as preeclampsia, preterm birth, premature rupture of membranes, and pregnancy loss. Additionally, their pregnancy may be complicated by lupus nephritis, a renal and often severe manifestation of lupus flare that presents similarly to preeclampsia.

Dr. Julia Simard and Amadeia Rector will explore the feasibility of disentangling a lupus nephritis flare from preeclampsia. They will go over their recent pilot work, which looks at a series of pregnant patients with SLE diagnosed with preeclampsia that received prenatal care at Lucile Packard Children’s Hospital and were managed for their lupus by Stanford Health Care. Their work aims to characterize the prenatal and postpartum management of a high-risk lupus pregnancy and identify any clinical patterns that may help distinguish preeclampsia from lupus nephritis.

May 3, 2021 12:00 PM in Pacific Time (US and Canada)

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Julia Simard, ScD
Associate Professor of Epidemiology and Population Health @Stanford School of Medicine
Julia Fridman Simard, ScD, is an Associate Professor of Epidemiology and Population Health, and, by courtesy, of Medicine in Immunology and Rheumatology at Stanford University School of Medicine. While at the Karolinska Institute from 2008-2012, Dr. Simard initiated a Swedish national register linkage, that was foundational for studies of maternal and fetal outcomes in systemic lupus pregnancy and a series of projects focused on the diagnosis of preeclampsia and comorbid outcomes including stroke, infection, and mortality. In addition to a series of projects evaluating the role of hydroxychloroquine in lupus pregnancy and preeclampsia, and misclassification of preeclampsia, Dr. Simard’s lab investigates how misclassification, missed opportunities, and misdiagnosis contribute to disparities in complex conditions such as systemic lupus.
Amadeia Rector, MPH
Research Associate, Epidemiology and Population Health @Stanford School of Medicine
Amadeia Rector, MPH, is a Research Associate to Professor Julia Simard in the Department of Epidemiology and Population Health at the Stanford University School of Medicine. She has previously worked for the San Francisco Department of Public Health in HIV/AIDS surveillance and research, where she first garnered an interest in behavioral epidemiology. Her present interests are in studying the intersection between maternal morbidity, autoimmune conditions, the social determinants of health, and postpartum care. Currently, she is working on several projects with Dr. Simard, such as investigating the role of hydroxychloroquine in preeclampsia and lupus pregnancies as well as disentangling the potential misclassification of preeclampsia in lupus pregnancies. Her hopes are to learn from the experts in maternal fetal medicine, immunology and rheumatology, and epidemiology to better inform and inspire her research.