Brain development is a remarkable process in which cells proliferate, differentiate, migrate, and connect to form functional neural circuits. One of the main challenges in understanding the programs of underlying brain development, and how they go awry in neuropsychiatric disease, is the lack of direct access to intact, functioning human brain tissue for detailed investigation and manipulation. Towards this objective, my laboratory developed tridimensional, self-organizing, cellular preparations known as brain assembloids and brain region-specific organoids. In this talk, Dr. Pasca will illustrate how these organoids generate and manipulate human stem cell-derived neural ensembles over months to years in vitro and in vivo to understand how neurons derived from patients with neuropsychiatric disease find their position, how they mature, and how they communicate.
Speaker: Sergiu P. Pasca, MD, Associate Professor of Psychiatry and Behavioral Sciences, Stanford School of Medicine